Endocrine Abstracts

Diabetes mellitus (DM) is a metabolic disease, which is accompanied by systemic damage to organs, including the central nervous system. Clinically, these changes are associated with cognitive impairment, the pathogenesis of which is also largely heterogeneous.Objective: To evaluate the role of tau-protein in the diagnosis of cognitive impairment in patients with type 1 and type 2 diabetes.Materials and methods: The study was tested...

Diabetic retinopathy (DR), is the cause of population invalidization which is diagnosed in 30–90% of patients.Purpose - to examine vitamin D levels in patients with diabetic retinopathy.Materials and methods: Under our supervision, there were 48 patients (93 eyes). Among examined 26 patients had nonproliferative form DR and 19 – proliferative DR.Results: Among the patients with type 1 diabetes 23 (5...

Context: Better, reproducible and structured methods of assessing care provided to endocrine patients are needed. Similarly, access to regional units and referral pathways could be improved with nationally agreed standards for waiting times.Objective: To gain views on the current level of patient care and how services might be improved using a 360-degree assessment process.Method: Three web based surveys were created using SurveyMo...

Background: Radioiodine is a safe and effective treatment for Graves’ disease. Iatrogenic hypothyroidism is very common after treatment, but its onset is unpredictable. Even a short episode of hypothyroidism can result in significant morbidity and ideally should be avoided. In our centre a standard dose of radioiodine (400 MBq) is used, but for historical reasons two different protocols are used after radioiodine: Regimen A: regular clinical and biochemical monitoring and...

Introduction: Improved survival in childhood acute lymphoblastic leukaemia (ALL) has highlighted the importance of recognising and preventing skeletal morbidity. This study aims to assess bone health of ALL patients and compare this to other paediatric patients with chronic illness.Methods: Dual energy absorptiometry (DXA) scan results for total body bone mineral density (TBBMD), lumbar spine bone mineral apparent density (LSBMAD) and total body less hea...

Background: Sales of iodized table salt (household use, bulk containers) have been flat in Germany since 1996/97. Nevertheless, the amount of iodide excreted with the urine has been steadily on the rise in the German population since 1993.Aim of the study: We investigated the beverage iodine levels as possible source of the increased input of iodine into the food chain. No systematic studies on this topic have yet been carried out in Germany.<p class...

In 24 years old woman in March 2007 was diagnosed acromegaly (somatoprolactinoma) an active phase, hyperprolactinemia. Manifestations: rugged features, amenorrhea, galactorrhea, fasting GH – 144 ng/ml (N<10 ng/ml), IGF-1 – 586 ng/ml (N 48–450 ng/ml), PRL – 6726 mU/l (N 40–530 mU/l). According to pituitary MRT a tumor volume was 14.4 cm3, with supra- and infrasella growth. She was operated in May 2007: transnal transs...

A 34-year-old Caucasian male with type 1 diabetes, diabetic nephropathy and secondary hyperparathyroidism was electively admitted for parathyroidectomy. He is on regular peritoneal dialysis and is on the renal transplant list.On admission his PTH was 215.3 and corrected calcium was 2.01. Other biochemical parameters remained stable. He uneventfully underwent a total parathyroidectomy. No implantation of any of the parathyroid glands was done. He did not ...

Objective: Appendiceal carcinoid is an uncommon neuroendocrine condition that can potentially give rise to a variation in management. We aimed to assess the occurrence and mode of presentation of carcinoid tumour of appendix, and any variation of its management.Methods: All appendicectomies that took place at a single institute between January 1995 and December 2005 were considered for study.Results: A total of 1941 appendicectomie...

Annexin A1 (ANXA1), a Ca2+ and phospholipid binding protein, serves as a paracrine/justacrine mediator of glucocorticoid action in the neuroendocrine system. Within the anterior pituitary gland ANXA1 is produced by folliculo-stellate (FS) cells and, following serine-27 phosphorylation (Ser27-P) and membrane translocation, acts on adjoining corticotroph cells to suppress ACTH release via a mechanism involving formyl peptide receptor (FPR) activation. To ex...